May 16, 20193ce

The Benefits of Snail Mucin in Skin Care

If you’re a fan of Japanese and Korean skincare and beauty products then you have likely come across serums and essences containing ‘snail mucin’, but what is snail mucin? And, more to the point, what are the benefits of snail mucin in skincare?

What Is Snail Mucin?

Snail mucin is another name for snail secretion filtrate, or ‘snail slime’ and is an animal-derived growth factor. Growth factors are high molecular weight peptides that encourage wound healing and tissue repair. The growth factors in snail mucin are highly beneficial to the snail and enable it to self-heal after injuries.

These regenerative effects are due to the complex chemical composition of snail mucin. A chemical analysis revealed that snail mucin contained various different substances, including allantoin, collagen, elastin, glycolic acid, hyaluronic acid, and natural antibacterials.

You probably recognise most of these substances as key ingredients in various anti-aging and moisturising skin care products – which is one of the reasons snail mucin has become such a popular skin care ingredient.

The most biologically active form of snail mucin and the one most commonly used in skin care products is derived from the Cryptomphalus aspersa mollusk, also known as the brown garden snail.

These snails have eight different types of secreting glands that secrete four different types of mucus; protein, calcium, pigments, and lipids. The mucus secreted depends on the way the snail is stimulated. For example, with normal stimulation, the mucin secreted provides lubrication (this type of mucus can be seen in a ‘snail trail’). In contrast, when the snail is disturbed or feels threatened, it releases a foamy secretion. It is the latter of these mucins that is used in skincare and contains the beneficial substances mentioned above.

The secretion from the Cryptomphalus aspersa mollusk is a mixture of glandular secretions from the mucinous, albuminous, and salivary glands, with each secretion responsible for different therapeutic effects. The secretion from the mucinous gland has a restorative effect, the secretion from the albuminous gland provides antibiotic effects, and the secretion of the salivary gland has a digestive and penetrative effect that can help exfoliate and deep-clean the skin.

The History of Snail Mucin

The medicinal use of snail mucin dates back to Ancient Greece where Hippocrates (the ‘father of medicine’) recommended the use of crushed snails to treat inflammatory skin conditions.

Fast forward a millennium, and a few thousand miles away from Ancient Greece, Chilean snail farmers were experiencing soft and smooth hands after regularly handling snails for the French food market. Not only were their hands smoother and softer, but any wounds or grazes appeared to heal faster with no scarring. This led to the first snail mucin-based skincare brand.

A further healing observation was made by a Spanish oncologist, Dr. Rafael Abad, who was treating snails with radiation therapy and noticed that they were producing a different type of secretion under this stress that helped their wounds to heal. When this secretion was applied to the radiation burns of human subjects, a similar wound healing response was observed.

In fact, snail mucin has been successfully used for over 15 years to treat radiation dermatitis. Dr. Abad also recommended, in his 1996 patent, that snail mucin could be successfully used to treat radiation dermatitis, all types of burns (including radiation, chemical, and thermal burns), slow healing wounds and ulcers, and to prevent UV radiation-induced skin cancer. He also suggests that snail mucin would be beneficial in the treatment of wrinkles and stretch marks.

It is no surprise then that snail mucin can be found in a number of cosmetic products nowadays and offers a wide variety of skin benefits. So what are the benefits of snail mucin in skin care? Let’s have a look at what scientific studies are available to answer this question.

What Are The Benefits Of Snail Mucin In Skin Care?

As previously mentioned, snail mucin is an animal-derived growth factor and high-molecular-weight peptide. It also contains a number of ingredients that are known to be beneficial to the skin, such as allantoin, glycolic acid, and hyaluronic acid.

As there aren’t a huge number of research studies that specifically investigate the skin benefits of snail mucin outside of its medical applications, let’s first look at why snail mucin should provide skin benefits in theory.

Snail Mucin As A Growth Factor/ HMW Peptide

Growth factors are peptides that act as chemical messengers to regulate various cell processes, including proliferation and formation of the extracellular matrix. This means they are essential in wound healing and tissue repair processes. Topically applied growth factors have demonstrated effectiveness at enhancing wound healing and stimulating the production of collagen.

However, growth factors have a large molecular weight which makes it difficult for them to penetrate the stratum corneum (the outer layer of the skin) barrier. It is hypothesised that topical growth factors enter the dermis by penetrating the hair follicles rather than the stratum corneum. Once they have entered the dermis they can then signal the production of endogenous growth factors.

As mentioned earlier, snail mucin is made up of different secretions. The secretion from the salivary gland has an exfoliating and penetrative effect. This may mean that the growth factors found in snail mucin are more readily absorbed due to this penetration enhancement.

Benefits of Snail Mucin and Its Complex Chemical Composition

Snail mucin contains a number of complex chemicals that are widely known to be beneficial in skin care products. Out of the ingredients with the most cited benefits appear to be allantoin, glycolic acid, and hyaluronic acid. In addition, snail mucin contains natural antibacterials which provide a wide range of benefits for the skin.

Allantoin

Allantoin is used in cosmetics as a skin conditioning agent and is approved for use as a skin protectant by the FDA. It is reported to have keratolytic, hydrating, epithelializing, and anti-irritant activitiesand has been used for more than 60 years to treat, prevent, and reduce scars and keloids with a number of scientific studies to back up allantoin's scar reducing ability.

In one study, a gel containing allantoin was applied to injured skin within 3 weeks of the injury taking place. After 2-3 months of treatment with allantoin gel, scars showed statistically significant improvements with less redness, more pliability, less pain, and reduced height and width. This study had a particularly large sample size but was purely observational and had no control group, so it is hard to determine whether the scars may have improved significantly within this time frame without the application of allantoin gel.

However, other randomised controlled studies have found improved wound healing and reduced scarring with the application of gels containing allantoin compared to control gels.

Glycolic Acid

Glycolic acid is an alpha-hydroxy acid derived from sugar cane that acts as a chemical exfoliant to remove dead skin cells and loosen the top layer of skin.

One of the most widely reported beneficial effects of glycolic acid for skin is its ability to reduce premature aging. This is largely due to its ability to increase collagen, improve the quality of elastic fibers, and shrink pores for a smoother complexion.

Furthermore, topical glycolic acid can increase epidermal thickness and epidermal and dermal hyaluronic acid levels. Thus glycolic acid can improve skin appearance, texture, and function by increasing skin hydration.

Other studies have demonstrated that the skin benefits of glycolic acid go beyond its ability to reduce premature aging. For example, 10% topical glycolic acid can significantly improve the appearance of acne after 45 days of use.

Glycolic acid can also reduce skin pigmentation. This is due to its exfoliant effect which speeds up the rate of skin cell turnover so that pigment can be lost more quickly.

Hyaluronic Acid

Hyaluronic acid is a glycosaminoglycan that can bind up to 1000 times its weight in water. This means that the hyaluronic acid content of the epidermis and dermis helps to regulate skin hydration levels and the stratum corneum barrier function.

When applied to the skin, hyaluronic acid forms a film that can reduce transepidermal water loss (TEWL) and protects the stratum corneum. It also acts as a humectant to draw water into the skin and increase the water content of the epidermis.

Hyaluronic acid can instantly improve the appearance of fine lines and wrinkles and improve skin hydration after only 15 minutes of application and after 8 weeks of use, these improvements become more significant and long-lasting.

According to some research, hyaluronic acid also plays a part in the wound healing process by creating an early provisional matrix or ‘scaffold’, along with fibrin, to allow the migration of cells to the wound site. This allows for the creation of a more stable and permanent matrix that is mainly composed of collagen.

Natural Antibacterials

An antibacterial is basically anything that can destroy or prevent the growth or multiplication of bacteria. One skin condition that particularly benefits from topical antibacterials is acne. This is due to the fact that one of the main causes of acne is an overgrowth of the p-acnes bacteria.

In addition, antibacterials can aid in the wound healing process by preventing infection.

The Benefits of Snail Mucin in Theory

The fact that snail mucin is a growth factor that contains allantoin, glycolic acid, hyaluronic acid, and antibacterial agents means that it may possess a number of skin benefits in theory.

Based on this research, some of the ways in which snail mucin may benefit the skin include:

Improving wound healing
Preventing scarring
Reducing existing scarring
Reducing premature aging due to UV exposure (photoaging)
Improving collagen production
Improving skin hydration
Increasing skin cell turnover
Reducing pigmentation
Preventing the growth of bacteria
Improving skin texture

This means that snail mucin may be an effective treatment for

Poorly healing wounds
Unsightly scars
Fine lines and wrinkles
Dehydrated and dry skin
Post-inflammatory hyper-pigmentation and melasma
Post-inflammatory erythema
Acne
Enlarged pores

The Cosmetic & Anti-Aging Benefits of Snail Mucin

One study recruited 15 women who were required to apply an 8% snail mucin formulation every morning and a 40% snail mucin formulation every night for 3 months. In addition to the significant 40% reduction in pigmentation, the depth of wrinkles was reduced by up to 30%. All participants experienced smoother and more hydrated skin, with the majority also experiencing improved skin elasticity.

In another study investigating the cosmetic applications of snail mucin, 12 subjects applied a facial cream containing snail mucin and donkey milk serum every day for 40 days. Evaluations were performed 2 hours after the first application as well as at the end of the 40-day period. The results demonstrated that skin elasticity, skin hydration, and wrinkle height were significantly improved both in the short-term (2hrs) and long-term (40days).

Another study recruited 40 participants into a 12-week study of a snail mucin formulation on various signs of aging. In this study, skin elasticity was improved by 39%, skin roughness was improved by 53%, skin brightness was improved by 26%, and irregular pigmentation was reduced by 12%.

In another study, 120 women applied various formulations of snail mucin (depending on their skin type – either serum or cream) with added peptides and antioxidants twice daily for 12 weeks. Skin evaluations took place at 45 and 90 days and assessed skin hydration, softness, firmness, elasticity, lining, expression lines, nasolabial grooves, and fine lines. All parameters assessed were significantly improved after 40 days, with progressive improvement after 90 days. Of note is the improvement in skin hydration by 91% after the 90-day treatment.

The addition of other peptides and antioxidants into the formulations in this study make it hard to identify whether the cause of the skin improvements was from snail mucin, peptides, antioxidants, or the combination of all three. Although, research suggests that snail mucin itself has antioxidant effects.

However, in a 14-week study, where 25 patients with moderate to severe facial photodamage applied an emulsion containing 8% snail mucin and a liquid serum containing 40% snail mucin to one side of their face and a control cream to the other, there was a significant improvement in crow’s feet wrinkles and skin texture. In addition, the patients reported a significant visual improvement in their fine lines after 8-weeks of use.

A Quick Summary Of The Benefits Of Snail Mucin

Snail mucin has been used since ancient times for its skin healing benefits. A number of research studies have demonstrated that snail mucin can significantly increase the rate of wound healing.

This healing effect appears to be due to the complex chemical composition of snail mucin and its ability to increase the production of new skin cells, prevent the death of existing skin cells, and enable the movement of skin cells to the wound site.

More recent research has highlighted the antioxidant, antimicrobial, and antitumoral effects of snail mucin which suggests that it has a broader range of benefits for the skin.

Considering that a number of anti-aging treatments, such as laser treatments and microneedling, exert their anti-aging effects by creating a wound healing response, it is highly likely that snail mucin can have anti-aging benefits.

Based on the chemical composition of snail mucin and the existing research, snail mucin may provide a wide-range of cosmetic skin benefits, including: